Open AccessProspective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms
Author(s) -
Maeve A. Lowery,
Winston Wong,
Emmet Jordan,
Jonathan W. Lee,
Yelena Kemel,
Joseph Vijai,
Diana Mandelker,
Ahmet Zehir,
Marinela Capanu,
Erin SaloMullen,
Angela G. Arnold,
Kenneth H. Yu,
Anna M. Varghese,
David P. Kelsen,
Robin Brenner,
Erica Kaufmann,
Vignesh Ravichandran,
Semanti Mukherjee,
Michael F. Berger,
David M. Hyman,
David S. Klimstra,
Ghassan K. AbouAlfa,
Catherine Tjan,
Christina M. Covington,
Hannah Maynard,
Peter J. Allen,
Gökçe Aşkan,
Steven D. Leach,
Christine A. Iacobuzio–Donahue,
Mark E. Robson,
Kenneth Offit,
Zsofia K. Stadler,
Eileen M. O’Reilly
Publication year - 2018
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/djy024
Subject(s) - palb2 , pancreatic cancer , loss of heterozygosity , germline , medicine , pancreas , prospective cohort study , pathological , oncology , cohort , gastroenterology , germline mutation , cancer , cancer research , biology , gene , genetics , allele , mutation
Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association to facilitate identification of prognostic and/or predictive biomarkers and examine potential therapeutic implications.
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