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A New Front Today, those efforts are proceeding on dual fronts. Whereas scientists 10 years ago were concerned only with multidrug resistance against chemotherapy, those working today must also contend with single-drug resistance to newer, targeted therapies such as imatinib (Gleevec), a drug for chronic myelogenous leukemia (CML) and other cancers that inactivates a cancer-inducing protein called Bcr-Abl. Unlike chemotherapy — which kills rapidly dividing cells regardless of whether they’re cancerous — targeted therapies interfere with specifi c molecules involved in cancer and tumor growth. The new era of targeted therapy was supposed to leave chemotherapy behind and multidrug resistance behind with it. That’s because re

Resistance Revisited: Looking Back at 10 Years of Multidrug Resistance Research