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Prostate-specific antigen (PSA) level is typically used as a dichotomous test for prostate cancer, resulting in overdiagnosis for a substantial number of men. The rate at which serum PSA levels change (PSA velocity) may be an important indicator of the presence of life-threatening disease.

Detection of Life-Threatening Prostate Cancer With Prostate-Specific Antigen Velocity During a Window of Curability