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After considerable debate in the medical literature about the existence of de novo cancer and the classification of colorectal polyps and their relationship to cancer (4), the concept of the adenoma–carcinoma sequence emerged in the 1970s as the dominant morphogenetic explanation of colorectal cancer (5). The hyperplastic polyp was recognized as a frequently occurring lesion, but common knowledge held that its only importance resided in the need to distinguish it from the adenoma because the hyperplastic polyp was regarded as having no malignant

Origin of Colorectal Cancers in Hyperplastic Polyps and Serrated Adenomas: Another Truism Bites the Dust