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The article by Fabian et al. (1) regarding short-term prediction of breast cancer development by fine-needle aspiration cytology may be an important addition, certainly for testing in the area of cancer prediction and breast cancer risk. However, on page 1218 of the article, the authors note that many of the patients had dense mammograms. This is a variable that is not considered in the analysis, despite the fact that many others are considered. Indeed, the ability to obtain samples of breast cells and to detect the presence of hyperplasia (2) may be closely associated with dense mammograms, and this variable, also associated with breast cancer risk (3), should be added to the analysis in future studies of aspirated samples for risk analysis.

RESPONSE: Re: Short-Term Breast Cancer Prediction by Random Periareolar Fine-Needle Aspiration Cytology and the Gail Risk Model