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As reported in a recent article in the Journal, Joseph and Isaacs (1) tried to combine Linomide® with other antiangiogenic agents known to inhibit tumorassociated macrophages (TAMs) to evaluate their joint antitumor effects. Unfortunately, the combination of Linomide with other antiangiogenic agents did not result in potentiation of therapeutic efficacy. Instead, one of these agents, pentoxifylline, inhibited the an-

Re: Macrophage Role in the Anti-Prostate Cancer Response to One Class of Antiangiogenic Agents