Open AccessaHIF: a Natural Antisense Transcript Overexpressed in Human Renal Cancer and During Hypoxia
Author(s) -
Catherine Thrash-Bingham,
Kenneth D. Tartof
Publication year - 1999
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/91.2.143
Subject(s) - messenger rna , untranslated region , biology , antisense rna , gene , cancer research , hypoxia inducible factors , microbiology and biotechnology , gene expression , transcription (linguistics) , kidney , endocrinology , genetics , linguistics , philosophy
Nonpapillary renal carcinoma is the predominant form of human kidney cancer and represents a distinct disease entity, morphologically and molecularly, from papillary renal carcinoma. We have discovered a natural antisense transcript that is complementary to the 3' untranslated region of hypoxia inducible factor alpha (HIF1alpha) messenger RNA (mRNA) and is strikingly overexpressed specifically in nonpapillary kidney cancer. HIF1alpha encodes a protein that is known to have two important functions: 1) to act as a transcription factor for hypoxia inducible genes and 2) to stabilize p53 protein during hypoxia. Because of the importance of HIF1alpha, we have characterized this natural antisense transcript, which we have named "aHIF."
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