Open AccessAlterations of INK4A and INK4B Genes in Adult Soft Tissue Sarcomas: Effect on Survival
Author(s) -
Irene Orlow,
Marija Drobnjak,
ZuoFeng Zhang,
Joshua P. Lewis,
James M. Woodruff,
Murray F. Brennan,
Carlos CordonCardo
Publication year - 1999
Publication title -
jnci journal of the national cancer institute
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.797
H-Index - 356
eISSN - 1460-2105
pISSN - 0027-8874
DOI - 10.1093/jnci/91.1.73
Subject(s) - biology , gene , cancer research , exact test , retinoblastoma protein , multiplex ligation dependent probe amplification , polymerase chain reaction , point mutation , tumor suppressor gene , genetics , mutation , exon , medicine , cell cycle , carcinogenesis
The INK4A and INK4B genes map to chromosome 9p21, with the INK4A gene encoding two protein products, p16 and pl9ARF. Alterations of the INK4A and INK4B genes occur frequently in certain primary malignant neoplasms. This study was undertaken to evaluate the frequency of INK4A and INK4B gene alterations in a cohort of adult soft tissue sarcomas.
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