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brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 1989;37:159–64. (34) Beaulieu E, Demeule M, Pouliot JF, Averill-Bates DA, Murphy GF, Beliveau R. P-glycoprotein of blood brain barrier: cross-reactivity of Mab C219 with a 190 kDa protein in bovine and rat isolated brain capillaries. Biochim Biophys Acta 1995;1233:27–32. (35) Rao VV, Anthony DC, Piwnica-Worms D. MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res 1994;54:1536–41. (36) Rao VV, Anthony DC, Piwnica-Worms D. Multidrug resistance Pglycoprotein monoclonal antibody JSB-1 crossreacts with pyruvate carboxylase. J Histochem Cytochem 1995;43:1187–92. (37) Georges E, Bradley G, Gariepy J, Ling V. Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies. Proc Natl Acad Sci U S A 1990;87:152–6. (38) Ng WF, Sarangi F, Zastawny RL, Veinot-Drebot L, Ling V. Identification of members of the P-glycoprotein multigene family. Mol Cell Biol 1989; 9:1224–32. (39) Scheper RJ, Bulte JW, Brakkee JG, Quak JJ, van der Schoot E, Balm AJ, et al. Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance. Int J Cancer 1988; 42:389–94. (40) Hamada H, Tsuruo T. Functional role for the 170to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies. Proc Natl Acad Sci U S A 1986;83:7785–9. (41) Georges E, Tsuruo T, Ling V. Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody. J Biol Chem 1993; 268:1792–8. (42) Rittmann-Grauer LS, Yong MA, Sanders V, Mackensen DG. Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft. Cancer Res 1992;52:1810–6. (43) Mechetner EB, Roninson IB. Efficient inhibition of P-glycoproteinmediated multidrug resistance with a monoclonal antibody. Proc Natl Acad Sci U S A 1992;89:5824–8. (44) Arceci RJ, Stieglitz K, Bras J, Schinkel A, Baas F, Croop J. Monoclonal antibody to an external epitope of the human mdr1 P-glycoprotein. Cancer Res 1993;53:310–7.

Can p53 Status Resolve Paradoxes Between Human and Non-Human Retinoblastoma Models?