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A variety of studies have supported the finding that regular intake of aspirin (acetylsalicylic acid) or nonsteroidal anti-inflammatory agents can affect colorectal cancer carcinogenesis. These agents inhibit the synthesis of prostaglandins. High levels of prostaglandins are observed in colon cancer tissues.

Suppression of Human Colorectal Mucosal Prostaglandins: Determining the Lowest Effective Aspirin Dose