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Hormonal imbalance characterized by excessive production of growth hormone (GH) and a low circulating concentration of insulin-like growth factor (IGF)-1 has been demonstrated in individuals with various serious conditions. However, little is known about changes in the GH-IGF-1 axis in cancer patients.

Disturbance of the Growth Hormone–Insulin-like Growth Factor-1 Axis Associated with Poor Performance Status in Patients with Solid Tumors