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The MDR1 gene encodes P-glycoprotein (PGP), which plays an important role in mediating multidrug resistance to chemotherapeutic agents. Polymorphisms in the MDR1 gene may have an impact on the expression and function of PGP, thereby influencing the response to chemotherapy.

MDR1 Polymorphisms Predict the Response to Etoposide–Cisplatin Combination Chemotherapy in Small Cell Lung Cancer