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Background:  Cisplatin-based chemotherapy is the mainstay of the treatment for advanced urothelial cancer, but patients with renal insufficiency before therapy are usually contraindicated to receiving platinum-based chemotherapy. Paclitaxel is one of the most promising agents against advanced urothelial carcinoma in recent trials and it can be easily tolerated even in patients with compromised renal function. We conducted a study in order to evaluate the efficacy and safety of paclitaxel as a first-line therapy in advanced urothelial carcinoma patients.

japanese journal of clinical oncology

Single Agent Paclitaxel as a First-line Therapy in Advanced Urothelial Carcinoma: Its Efficacy and Safety in Patients Even With Pretreatment Renal Insufficiency