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Background:  Bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) is the first orally given platinum complex that shows  in vitro  cytotoxicity comparable to that of cisplatin and  in vivo  cytotoxicity superior to those of cisplatin and carboplatin.

japanese journal of clinical oncology

Pharmacokinetic and Pharmacodynamic Analysis of Bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) Administered Once a Day for Five Consecutive Days: A Phase I Study