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Background:  It has been proven that cytokeratins (CKs) are useful tumor markers for the follow-up, treatment monitoring and prognosis evaluation of lung cancer and among these, tissue polypeptide antigen (TPA) plays an important role. Nevertheless, only a small number of studies have been reported about their diagnostic capacity. Bronchoalveolar lavage (BAL) can be divided into two fractions: bronchiolar (BF) and alveolar (AF). For the above reasons, our aims were ( 1 ) to analyze the diagnostic usefulness of TPA in the BAL of lung cancer patients and ( 2 ) to observe if, in lung cancer patients, TPA levels in the two BAL fractions are different. This should mean that the study of tumor markers in the BAL should be carried out in both fractions to increase their diagnostic capacity.

An Evaluation of Tissue Polypeptide Antigen (TPA) in the Two Bronchoalveolar Lavage Fractions of Lung Cancer Patients