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Cisplatin is widely used in combination chemotherapy against a variety of tumors; however, the optimal administration schedule of cisplatin is still controversial. To clarify the pharmacokinetic differences according to the administration schedules of cisplatin, we compared three different administration schedules of cisplatin such as single short-term infusion, daily short-term infusion and daily continuous infusion in combination with 5-fluorouracil. Preliminary clinical responses and toxicities were also investigated.

japanese journal of clinical oncology

Pharmacokinetics of Cisplatin in Combined Cisplatin and 5-Fluorouracil Therapy: A Comparative Study of Three Different Schedules of Cisplatin Administration