English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Iodine-containing trihalomethanes (iodo-THMs) are formed as disinfection byproducts when iodide-containing water is disinfected using chloramination process. Subsequent water use may lead to human exposure to iodo-THMs. Because of health concerns surrounding exposure to iodo-THMs, a rapid, reliable, and high-throughput analytical method was developed to quantify trace levels of two iodo-THMs: dichloroiodomethane (IDCM) and bromochloroiodomethane (IBCM) in human blood. These analytes from the headspace above blood samples were extracted using solid-phase microextraction. Analytes were then desorbed and separated by capillary gas chromatography and analyzed by high-resolution mass spectrometry with multiple ion monitoring. This method utilizes stable isotope dilution to quantify parts-per-trillion levels of all analytes, with excellent precision of &lt; 9% coefficient of variation. At three spiked levels, method accuracy of IDCM and IBCM ranged between 6 and 20% difference when comparing spiked and measured amounts. The method limit of detection was 2 ng/L for both IDCM and IBCM. This selective, sensitive, and rapid method will help to assess human exposure to iodo-THMs and to study potential associations between exposure and adverse health outcomes.

journal of analytical toxicology.

Quantification of Dichloroiodomethane and Bromochloroiodomethane in Human Blood by Solid-Phase Microextraction Coupled with Gas Chromatography-High-Resolution Mass Spectrometry*