English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

We present an analytical method for the determination of heroin, free 6-acetylmorphine (6-AM), and free morphine in blood, urine, and vitreous humor. This method is used in postmortem cases where heroin is the suspected cause of death. The analytical protocol includes the following steps: liquid-liquid extraction at pH 9.5, propionylation at room temperature of 6-AM, and morphine by propionic anhydride using 4-dimethylaminopyridine as catalyst. Neither heroin nor diethylnalorphine (internal standard) is transformed during this derivatization. The reaction products are analyzed using full-scan (250-405 amu) ion trap gas chromatography-mass spectrometry. This method provides a baseline separation and distinctive mass spectrum of each compound of interest. Reproducibility and an evaluation of analysis parameters are also presented.

Determination of Heroin, 6-Acetylmorphine, and Morphine in Biological Fluids Using their Propionyl Derivatives with Ion Trap GC-MS