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A new, simple, and sensitive kinetic spectrophotometric method is described for analysis of cefadroxil by measurement of its absorbance at 470 nm after hydrolysis with NaOH at 80°C. Studies of the method's precision and accuracy gave a standard deviation of 0.44 μg/mL and a relative standard deviation of 1.93%. The method determines cefadroxil over the concentration range 10- 100 ug/mL. Calculated activation parameters were 12.42, 25.54, 26.25, and 69.00 Kcal/mole for AE*, AG*, Ahf, and AS*, respectively. Cefadroxil concentrations can be determined from the regression line equation y = 0.627x- 8.14 x 10"5, with a correlation coefficient of &amp;lt;1.0000. The method was validated by assay of cefadroxil in commercial capsules and tablets. Recoveries of common excipients were 99.6,100.00, 99.2, 99.6, and 100.4% for lactose, glucose, starch, sucrose, and fructose, respectively. Results were compared with those of a reference method. Calculated f and F values indicate no significant difference between the 2 methods. The degradation products of cefadroxil do not affect determination of cefadroxil.

A Kinetic Approach for Determination of Cefadroxil in Pharmaceuticals by Alkaline Hydrolysis