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Centralized and federated models for sharing data in research networks currently exist. To build multivariate data analysis for centralized networks, transfer of patient-level data to a central computation resource is necessary. The authors implemented distributed multivariate models for federated networks in which patient-level data is kept at each site and data exchange policies are managed in a study-centric manner.

journal of the american medical informatics association

A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research