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Meropenem plasma concentration above a pathogen's MIC over the whole dosing interval (100% ƒT&gt;MIC) is a determinant of outcome in severe infections. Significant variability of meropenem pharmacokinetics is reported in ICU patients.

journal of antimicrobial chemotherapy

Effect of renal clearance and continuous renal replacement therapy on appropriateness of recommended meropenem dosing regimens in critically ill patients with susceptible life-threatening infections