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The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these same strains to evaluate the efficacy of combinations of antibiotics with putative efflux pump inhibitors in vivo.

journal of antimicrobial chemotherapy

Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of <i>Pseudomonas aeruginosa</i> in a <i>Galleria mellonella in vivo</i> infection model

Enhanced efficacy of putative efflux pump inhibitor/antibiotic combination treatments versus MDR strains of Pseudomonas aeruginosa in a Galleria mellonella in vivo infection model