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In the final analysis, the self (S)-non-self (NS) discrimination is regulated by the sufficiency or insufficiency of effector T(h) (eT(h)) specific for the given antigen. We have described a model (Th genesis) for the origin of eT(h) based on an antigen-independent pathway from initial state T(h) (iT(h)) to eT(h), and on obligatory associative recognition of antigen (ARA) by an iT(h) and an eT(h) in order for the iT(h) to be activated. A computer analysis (referred to as Th genesis) was developed to evaluate this model that is extended here to describe the response to NS antigen. Th genesis fills in the missing element of the two-signal or ARA model for the S-NS discrimination, i.e. the origin of the primer eT(h). The conclusions from this analysis are compared with those of the other models for the origin of eT(h).

international immunology

A computerized model for the self-non-self discrimination at the level of the Th (Th genesis). II. The behavior of the system upon encounter with non-self antigens