Open AccessEvidence of Recent Genomic Evolution in Gonococcal Strains With Decreased Susceptibility to Cephalosporins or Azithromycin in the United States, 2014–2016
Author(s) -
Jesse C. Thomas,
Sandra Seby,
A. Jeanine Abrams,
Jack Cartee,
Sean Lucking,
Eshaw Vidyaprakash,
Matthew Schmerer,
Cau D. Pham,
Jaeyoung Hong,
Elizabeth Torrone,
Sancta St. Cyr,
William M. Shafer,
Kyle Bernstein,
Ellen N. Kersh,
Kim M. Gernert,
Antimicrobial-Resistant Neisseria gonorrhoeae Working Group,
Hillard Weinstock,
Catherine Dominguez,
Sopheay Hun,
Katie Kneupper
Publication year - 2019
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiz079
Subject(s) - neisseria gonorrhoeae , biology , mtrr , multilocus sequence typing , azithromycin , cephalosporin , antibiotic resistance , genetics , genotype , lineage (genetic) , clade , microbiology and biotechnology , virology , phylogenetic tree , antibiotics , gene , methylenetetrahydrofolate reductase
Given the lack of new antimicrobials or a vaccine, understanding the evolutionary dynamics of Neisseria gonorrhoeae is a significant public and global health priority. We investigated the emergence and spread of gonococcal strains with decreased susceptibility to cephalosporins and azithromycin using detailed genomic analyses of gonococcal isolates collected in the United States, 2014-2016.
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