Open AccessThe Latent Human Immunodeficiency Virus (HIV) Reservoir Resides Primarily in CD32−CD4+ T Cells in Perinatally HIV-Infected Adolescents With Long-Term Virologic Suppression
Author(s) -
Adit Dhummakupt,
Lilly Siems,
Dolly Singh,
Ya Hui Chen,
Thuy Anderson,
Aleisha Collinson-Streng,
Hao Zhang,
Purvish P. Patel,
Allison L. Agwu,
Deborah Persaud
Publication year - 2018
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiy461
Subject(s) - provirus , flow cytometry , virology , population , viral load , biology , virus , human immunodeficiency virus (hiv) , immunology , medicine , genetics , environmental health , gene , genome
High-level expression of the Fcγ receptor, CD32hi, on CD4+ T cells was associated with enhanced human immunodeficiency virus (HIV) infection of the latent reservoir in a study of adults receiving antiretroviral therapy. We tested the hypothesis that CD32 was the preferential marker of the latent HIV reservoir in virally suppressed, perinatally HIV-infected adolescents.
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