Open AccessRelationship Between Anemia, Malaria Coinfection, and Kaposi Sarcoma-Associated Herpesvirus Seropositivity in a Population-Based Study in Rural Uganda
Author(s) -
Angela Nalwoga,
Stephen Cose,
Stephen Nash,
Wendell Miley,
Gershim Asiki,
Sylvia Kusemererwa,
Robert Yarchoan,
Nazzarena Labò,
Denise Whitby,
Robert Newton
Publication year - 2018
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiy274
Subject(s) - coinfection , malaria , medicine , anemia , immunology , population , virology , biology , environmental health , human immunodeficiency virus (hiv)
We examined anemia and malaria as risk factors for Kaposi sarcoma-associated herpesvirus (KSHV) seropositivity and antibody levels in a long-standing rural Ugandan cohort, in which KSHV is prevalent. Samples from 4134 children, aged 1-17 years, with a sex ratio of 1:1, and 3149 adults aged 18-103 years, 41% of whom were males, were analyzed. Among children, malaria infection was associated with higher KSHV prevalence (61% vs 41% prevalence among malaria infected and uninfected, respectively); malaria was not assessed in adults. Additionally, lower hemoglobin level was associated with an increased prevalence of KSHV seropositivity, both in children and in adults.
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