Open AccessAbacavir Induces Arterial Thrombosis in a Murine Model
Author(s) -
Víctor ColladoDíaz,
Isabel Andújar,
Ainhoa SánchezLópez,
Samuel Orden,
María Amparo BlanchRuiz,
María Ángeles Martínez-Cuesta,
Ana BlasGarcía,
Juan V. Esplugues,
Ángeles Álvarez
Publication year - 2018
Publication title -
the journal of infectious diseases
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiy001
Subject(s) - abacavir , pharmacology , medicine , thrombosis , purinergic receptor , receptor , lamivudine , immunology , hepatitis b virus , virus
The purinergic system is known to underlie prothrombotic and proinflammatory vascular programs, making the profile of experimental actions demonstrated by abacavir compatible with thrombogenesis. However, direct evidence of a prothrombotic effect by the drug has been lacking.
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