Open AccessAntigenic Characterization of a Novel Recombinant GII.P16-GII.4 Sydney Norovirus Strain With Minor Sequence Variation Leading to Antibody Escape
Author(s) -
Lisa C. Lindesmith,
Paul D. Brewer-Jensen,
Michael L. Mallory,
Kari Debbink,
Excel W. Swann,
Jan Vinjé,
Ralph S. Baric
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix651
Subject(s) - epitope , virology , antigenicity , antibody , monoclonal antibody , polyclonal antibodies , antigen , recombinant dna , biology , norovirus , antigenic variation , neutralization , virus , immunology , genetics , gene
Human noroviruses are the leading cause of acute gastroenteritis. Strains of the GII.4 genotype cause pandemic waves associated with viral evolution and subsequent antigenic drift and ligand-binding modulation. In November 2015, a novel GII.4 Sydney recombinant variant (GII.P16-GII.4 Sydney) emerged and replaced GII.Pe-GII.4 Sydney as the predominant cause of acute gastroenteritis in the 2016-2017 season in the United States.
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