Open AccessAn Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the “Perfect Storm”
Author(s) -
Laura J. Rojas,
George M. Weinstock,
Elsa De La Cadena,
Lorena Díaz,
Rafael Ríos,
Blake Hanson,
Joseph S. Brown,
Purva Vats,
Daniel Phillips,
Hoan Nguyen,
Kristine M. Hujer,
Adriana Correa,
Mark D. Adams,
Federico Pérez,
Erica Sodergren,
Apurva Narechania,
Paul J. Planet,
María Virginia Villegas,
Robert A Bonomo,
César A. Arias
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix524
Subject(s) - klebsiella pneumoniae , biology , phylogenetic tree , microbiology and biotechnology , evolutionary biology , genetics , gene , escherichia coli
Carbapenem resistance is a critical healthcare challenge worldwide. Particularly concerning is the widespread dissemination of Klebsiella pneumoniae carbapenemase (KPC). Klebsiella pneumoniae harboring blaKPC (KPC-Kpn) is endemic in many areas including the United States, where the epidemic was primarily mediated by the clonal dissemination of Kpn ST258. We postulated that the spread of blaKPC in other regions occurs by different and more complex mechanisms. To test this, we investigated the evolution and dynamics of spread of KPC-Kpn in Colombia, where KPC became rapidly endemic after emerging in 2005.
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