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Summary  In a setting of high tuberculosis and human immunodeficiency virus type 1 infection coprevalence, low prevalence of isoniazid monoresistance, treatment with daily standardized antituberculosis regimens throughout and high uptake of antiretroviral therapy were associated with low frequency of acquired drug resistance. Prevention of transmitted resistance should be prioritized.  In a setting of high tuberculosis and human immunodeficiency virus type 1 infection coprevalence, low prevalence of isoniazid monoresistance, daily treatment with standardized antituberculosis regimens throughout the study period, and high uptake of antiretroviral therapy were associated with low frequency of acquired drug resistance. Prevention of transmitted resistance should be prioritized.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Low Frequency of Acquired Isoniazid and Rifampicin Resistance in Rifampicin-Susceptible Pulmonary Tuberculosis in a Setting of High HIV-1 Infection and Tuberculosis Coprevalence