Open AccessParasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1
Author(s) -
Nicaise Tuikue Ndam,
Azizath Moussiliou,
Thomas Lavstsen,
Claire Kamaliddin,
Anja T. R. Jensen,
Atikatou Mama,
Rachida Tahar,
Christian W. Wang,
Jakob S. Jespersen,
Jules Alao,
Benoît Gamain,
Thor G. Theander,
Philippe Deloron
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix230
Subject(s) - endothelial protein c receptor , malaria , cerebral malaria , receptor , plasmodium falciparum , biology , virology , immunology , biochemistry , thrombin , platelet
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1 (ICAM-1), and endothelial protein C receptor (EPCR); however, cytoadhesion patterns typical for pediatric malaria syndromes and the associated PfEMP1 members are still undefined.
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