Open AccessThe Surface Protein SdrF Mediates Staphylococcus epidermidis Adherence to Keratin
Author(s) -
Sheetal Trivedi,
AnneCatrin Uhlemann,
Philippe HermanBausier,
Sean B. Sullivan,
Madeleine Sowash,
Elizabeth Y. Flores,
Sabrina Khan,
Yves F. Dufrêne,
Franklin D. Lowy
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix213
Subject(s) - keratin , staphylococcus epidermidis , keratinocyte , keratin 14 , biology , microbiology and biotechnology , chemistry , staphylococcus aureus , bacteria , cell culture , biochemistry , genetics , gene , transgene , genetically modified mouse
Staphylococcus epidermidis, a major component of skin flora, is an opportunist, often causing prosthetic device infections. A family of structurally related proteins mediates staphylococcal attachment to host tissues, contributing to the success of S. epidermidis as a pathogen. We examined the ability of the surface protein SdrF to adhere to keratin, a major molecule expressed on the skin surface.
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