Open AccessMulti-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum
Author(s) -
Ghizal Siddiqui,
Anubhav Srivastava,
Adrian S. Russell,
Darren J. Creek
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix156
Subject(s) - artemisinin , plasmodium falciparum , biology , metabolomics , proteomics , glutathione , mutant , drug resistance , quantitative proteomics , biochemistry , malaria , microbiology and biotechnology , enzyme , gene , bioinformatics , immunology
The emergence of artemisinin resistance in the malaria parasite Plasmodium falciparum poses a major threat to the control and elimination of malaria. Certain point mutations in the propeller domain of PfKelch13 are associated with resistance, but PfKelch13 mutations do not always result in clinical resistance. The underlying mechanisms associated with artemisinin resistance are poorly understood, and the impact of PfKelch13 mutations on cellular biochemistry is not defined.
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