Open AccessPlasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients
Author(s) -
Meike H. van der Ree,
Louis Jansen,
Zita Kruize,
Ad C. van Nuenen,
Karel A. van Dort,
R. Bart Takkenberg,
Hendrik W. Reesink,
Neeltje A. Kootstra
Publication year - 2017
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jix140
Subject(s) - hbsag , hbeag , hepatitis b virus , medicine , immunology , hepatitis b , microrna , virology , virus , biology , gene , biochemistry
Hepatitis B virus (HBV) modulates microRNA (miRNA) expression to support viral replication. The aim of this study was to identify miRNAs associated with hepatitis B e antigen (HBeAg) status and response to antiviral therapy in patients with chronic hepatitis B (CHB) , and to assess if these miRNAs are actively secreted by hepatoma cells.
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