Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses | Zendy

Tao Jiang | Zendy; JiaFu Jiang | Zendy; YongQiang Deng | Zendy; BaoGui Jiang | Zendy; Hang Fan | Zendy; Jianfeng Han | Zendy; Yi Hu | Zendy; Daomin Zhuang | Zendy; David Kargbo | Zendy; Xiaoping An | Zendy; Zhiqiang Mi | Zendy; Guangyu Zhao | Zendy; Wenwen Xin | Zendy; Yafang Tan | Zendy; Jun He | Zendy; Rongbao Gao | Zendy; Hong Wang | Zendy; Cao Chen | Zendy; Feng Wang | Zendy; Chunxiao Li | Zendy; Jianjun Zhao | Zendy; Yujun Cui | Zendy; Zhuchun Bei | Zendy; Ke Zhang | Zendy; Xueyi Shang | Zendy; Wenhui Zhang | Zendy; Guangqian Pei | Zendy; Yunfei Wang | Zendy; Wei Wang | Zendy; Peng Shu | Zendy; Wenli Liu | Zendy; Cheng Shi | Zendy; Shun-Ya Zhu | Zendy; Alex Kanu | Zendy; Brima Kargbo | Zendy; Bo Gao | Zendy; Yigang Tong | Zendy; Tongyu Fang | Zendy; WuChun Cao | Zendy

Open Access

Features of Ebola Virus Disease at the Late Outbreak Stage in Sierra Leone: Clinical, Virological, Immunological, and Evolutionary Analyses

Author(s) -

Tao Jiang,

JiaFu Jiang,

YongQiang Deng,

BaoGui Jiang,

Hang Fan,

Jianfeng Han,

Yi Hu,

Daomin Zhuang,

David Kargbo,

Xiaoping An,

Zhiqiang Mi,

Guangyu Zhao,

Wenwen Xin,

Yafang Tan,

Jun He,

Rongbao Gao,

Hong Wang,

Cao Chen,

Feng Wang,

Chunxiao Li,

Jianjun Zhao,

Yujun Cui,

Zhuchun Bei,

Ke Zhang,

Xueyi Shang,

Wenhui Zhang,

Guangqian Pei,

Yunfei Wang,

Wei Wang,

Peng Shu,

Wenli Liu,

Cheng Shi,

Shun-Ya Zhu,

Alex Kanu,

Brima Kargbo,

Bo Gao,

Yigang Tong,

Tongyu Fang,

WuChun Cao

Publication year - 2017

Publication title -

the journal of infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.69

H-Index - 252

eISSN - 1537-6613

pISSN - 0022-1899

DOI - 10.1093/infdis/jix061

Subject(s) - sierra leone , ebola virus , outbreak , virology , case fatality rate , virus , ebolavirus , disease , viral load , biology , immunology , medicine , epidemiology , economics , development economics

We performed Ebola virus disease diagnosis and viral load estimation for Ebola cases in Sierra Leone during the late stage of the 2014-2015 outbreak (January-March 2015) and analyzed antibody and cytokine levels and the viral genome sequences. Ebola virus disease was confirmed in 86 of 1001 (9.7%) patients, with an overall case fatality rate of 46.8%. Fatal cases exhibited significantly higher levels of viral loads, cytokines, and chemokines at late stages of infection versus early stage compared with survivors. The viruses converged in a new clade within sublineage 3.2.4, which had a significantly lower case fatality rate.

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