Open AccessDuring Hepatitis C Virus (HCV) Infection and HCV-HIV Coinfection, an Elevated Plasma Level of Autotaxin Is Associated With Lysophosphatidic Acid and Markers of Immune Activation That Normalize During Interferon-Free HCV Therapy
Author(s) -
Lenche Kostadinova,
Carey L. Shive,
Chelsey J. Judge,
Elizabeth Zebrowski,
Anita Compan,
Kelsey Rife,
Amy Hirsch,
Yngve Falck–Ytter,
Daniela Schlatzer,
Xiaolin Li,
Mark R. Chance,
Benigno Rodríguez,
Daniel L. Popkin,
Donald D. Anthony
Publication year - 2016
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiw372
Subject(s) - autotaxin , coinfection , hepatitis c virus , lysophosphatidic acid , immune system , immunology , hepatitis c , interferon , biology , virology , medicine , virus , receptor
Immune activation predicts morbidity during hepatitis C virus (HCV) infection and human immunodeficiency virus (HIV) infection, although mechanisms underlying immune activation are unclear. Plasma levels of autotaxin and its enzymatic product, lysophosphatidic acid (LPA), are elevated during HCV infection, and LPA activates immunocytes, but whether this contributes to immune activation is unknown.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom