Open AccessPositive Contribution of Adjuvanted Influenza Vaccines to the Resolution of Bacterial Superinfections
Author(s) -
Vanessa Zurli,
Marilena Gallotta,
Marianna Taccone,
Emiliano Chiarot,
Michela Brazzoli,
Federica Corrente,
Alessandra Bonci,
Daniele Casini,
Ennio De Gregorio,
Barbara C. Baudner,
Sylvie Bertholet,
Anja Seubert
Publication year - 2016
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiw048
Subject(s) - superinfection , vaccination , immunology , influenza a virus , virology , immune system , adjuvant , virus , biology , pneumonia , bacterial pneumonia , staphylococcus aureus , immunity , pathogen , microbiology and biotechnology , medicine , antibiotics , bacteria , genetics
Most preclinical studies assess vaccine effectiveness in single-pathogen infection models. This is unrealistic given that humans are continuously exposed to different commensals and pathogens in sequential and mixed infections. Accordingly, complications from secondary bacterial infection are a leading cause of influenza-associated morbidity and mortality. New vaccination strategies are needed to control infections on simultaneous fronts.
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