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Staphylococcus lugdunensis is an emerging cause of endocarditis. To cause endovascular infections, S. lugdunensis requires mechanisms to overcome shear stress. We investigated whether platelets and von Willebrand factor (VWF) mediate bacterial adhesion to the vessel wall and the cardiac valves under flow.

Shear-Resistant Binding to von Willebrand Factor AllowsStaphylococcus lugdunensisto Adhere to the Cardiac Valves and Initiate Endocarditis