Open AccessHLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
Author(s) -
Philippa C. Matthews,
Jonathan M. Carlson,
Apostolos Beloukas,
Amna Malik,
Pieter Jooste,
Anthony Ogwu,
Roger Shapiro,
Lynn Riddell,
Fabian Chen,
Graz Luzzi,
Gerald Jesuthasan,
Katie Jeffery,
Nebojša Jojić,
Thumbi Ndung’u,
Mary Carrington,
Philip Goulder,
Anna María Geretti,
Paul Klenerman
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv592
Subject(s) - immunology , hepatitis b virus , human leukocyte antigen , context (archaeology) , coinfection , hepatitis b , medicine , virology , antigen , virus , biology , paleontology
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8(+) T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.
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