Open AccessToll-like Receptor 4 Signaling on Dendritic Cells Suppresses Polymorphonuclear Leukocyte CXCR2 Expression and Trafficking via Interleukin 10 During Intra-abdominal Sepsis
Author(s) -
Meihong Deng,
Tao Ma,
Zhengzheng Yan,
Kent R. Zettel,
Melanie J. Scott,
Hong Liao,
A. Frank,
Adrián E. Morelli,
Chhinder P. Sodhi,
David J. Hackam,
Timothy R. Billiar
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv562
Subject(s) - sepsis , tlr4 , toll like receptor , immunology , immune system , acquired immune system , receptor , biology , dendritic cell , microbiology and biotechnology , innate immune system , medicine , biochemistry
Toll-like receptor 4 (TLR4) is a critical receptor involved in the sensing of gram-negative bacterial infection. However, the roles of TLR4 in sepsis are cell-type specific. Dendritic cells (DCs) are known to play a central role in microbial detection, alerting the immune system to the presence of infection and coordinating adaptive immune response. The goal of this study was to investigate the impact of DC-specific TLR4 signaling on host defense against intra-abdominal polymicrobial sepsis.
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