Open AccessPhenotype and Polyfunctional Deregulation Involving Interleukin 6 (IL-6)– and IL-10–Producing Monocytes in HIV-Infected Patients Receiving Combination Antiretroviral Therapy Differ From Those in Healthy Older Individuals
Author(s) -
Rebeca S. De Pablo-Bernal,
R. Ramos,
Miguel Genebat,
J. Cañizares,
Mohammed RafiiElIdrissi Benhnia,
María Ángeles MuñozFernández,
Yolanda M. Pacheco,
María Isabel Galvá,
M. Leal,
Ezequiel Ruíz-Mateos
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv520
Subject(s) - immunology , human immunodeficiency virus (hiv) , medicine , antiretroviral therapy , monocyte , interleukin , phenotype , deregulation , interleukin 2 , interleukin 6 , immunopathology , cytokine , virology , viral load , biology , economics , macroeconomics , gene , biochemistry
Despite the relevance of monocytes as promoters of the inflammatory response, whether human immunodeficiency virus (HIV) infection induces premature age-related changes to the phenotype and function of monocytes or whether these alterations are different and/or specifically driven by HIV remains to be mechanistically determined.
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