Open AccessFitness Costs of Drug Resistance Mutations in Multidrug-ResistantMycobacterium tuberculosis: A Household-Based Case-Control Study
Author(s) -
Phillip P. Salvatore,
Mercedes C. Becerra,
Pia Abel zur Wiesch,
Trevor Hinkley,
Davinder Kaur,
Alexander Sloutsky,
Ted Cohen
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv347
Subject(s) - mycobacterium tuberculosis , tuberculosis , multiple drug resistance , drug resistance , drug , virology , biology , tuberculosis control , medicine , microbiology and biotechnology , genetics , pharmacology , pathology
The projected long-term prevalence of multidrug-resistant (MDR) tuberculosis depends upon the relative fitness of MDR Mycobacterium tuberculosis strains, compared with non-MDR strains. While many experimental models have tested the in vitro or in vivo fitness costs of various drug resistance mutations, fewer epidemiologic studies have attempted to validate these experimental findings.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom