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The projected long-term prevalence of multidrug-resistant (MDR) tuberculosis depends upon the relative fitness of MDR Mycobacterium tuberculosis strains, compared with non-MDR strains. While many experimental models have tested the in vitro or in vivo fitness costs of various drug resistance mutations, fewer epidemiologic studies have attempted to validate these experimental findings.

Fitness Costs of Drug Resistance Mutations in Multidrug-ResistantMycobacterium tuberculosis: A Household-Based Case-Control Study