Open AccessA Bivalent Vaccine Based on a PB2-Knockout Influenza Virus Protects Mice From Secondary Pneumococcal Pneumonia
Author(s) -
Ryuta Uraki,
Zhenyu Piao,
Yukihiro Akeda,
Kiyoko IwatsukiHorimoto,
Maki Kiso,
Makoto Ozawa,
Kazunori Oishi,
Yoshihiro Kawaoka
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv341
Subject(s) - virology , virus , bivalent (engine) , streptococcus pneumoniae , nasal administration , microbiology and biotechnology , influenza a virus , biology , pneumococcal pneumonia , chemistry , antibiotics , organic chemistry , metal
Secondary bacterial infections after influenza can be a serious problem, especially in young children and the elderly, yet the efficacy of current vaccines is limited. Earlier work demonstrated that a replication-incompetent PB2-knockout (PB2-KO) influenza virus possessing a foreign gene in the coding region of its PB2 segment can serve as a platform for a bivalent vaccine.
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