Open AccessTrypanosomabrucei gambienseSpliced Leader RNA Is a More Specific Marker for Cure of Human African Trypanosomiasis ThanT. b. gambienseDNA: Table 1.
Author(s) -
Hamidou Ilboudo,
Oumou Camara,
Sophie Ravel,
Bruno Bucheton,
Veerle Lejon,
Mamadou Camara,
Jacques Kaboré,
Vincent Jamonneau,
Stijn Deborggraeve
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv337
Subject(s) - african trypanosomiasis , trypanosomiasis , trypanosoma brucei , rna , virology , biology , dna , parasite hosting , trypanocidal agent , immunology , microbiology and biotechnology , genetics , gene , world wide web , computer science
To assess the efficacy of treatment for human African trypanosomiasis, accurate tests that can discriminate relapse from cure are needed. We report the first data that the spliced leader (SL) RNA is a more specific marker for cure of human African trypanosomiasis than parasite DNA. In blood samples obtained from 61 patients in whom human African trypanosomiasis was cured, SL RNA detection had specificities of 98.4%-100%, while DNA detection had a specificity of only 77%. Data from our proof-of-concept study show that SL RNA detection has high potential as a test of cure.
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