Open AccessGenetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever
Author(s) -
Teske Schoffelen,
Anne Ammerdorffer,
Julia C.J.P. Hagenaars,
Chantal P. BleekerRovers,
Marjolijn Wegdam-Blans,
Peter C. Wever,
Leo A. B. Joosten,
J.W.M. van der Meer,
Tom Sprong,
Mihai G. Netea,
Marcel van Deuren,
Esther van de Vosse
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv113
Subject(s) - nod2 , coxiella burnetii , q fever , biology , immunology , single nucleotide polymorphism , tlr2 , pattern recognition receptor , genotype , virology , tlr4 , genetics , gene , innate immune system , immune system
Q fever is an infection caused by Coxiella burnetii. Persistent infection (chronic Q fever) develops in 1%-5% of patients. We hypothesize that inefficient recognition of C. burnetii and/or activation of host-defense in individuals carrying genetic variants in pattern recognition receptors or adaptors would result in an increased likelihood to develop chronic Q fever.
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