Open AccessTransport of Ebolavirus Nucleocapsids Is Dependent on Actin Polymerization: Live-Cell Imaging Analysis of Ebolavirus-Infected Cells
Author(s) -
Gordian Schudt,
Olga Dolnik,
Larissa Kolesnikova,
Nadine Biedenkopf,
Astrid Herwig,
Stephan Becker
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv083
Subject(s) - ebolavirus , virology , budding , live cell imaging , actin , biology , virus , cell , microbiology and biotechnology , ebola virus , genetics
Transport of ebolavirus (EBOV) nucleocapsids from perinuclear viral inclusions, where they are formed, to the site of budding at the plasma membrane represents an obligatory step of virus assembly. Until now, no live-cell studies on EBOV nucleocapsid transport have been performed, and participation of host cellular factors in this process, as well as the trajectories and speed of nucleocapsid transport, remain unknown.
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