Open AccessPersistence of Sulfadoxine-Pyrimethamine Resistance Despite Reduction of Drug Pressure in Malawi
Author(s) -
Elena Artimovich,
Kristan A. Schneider,
Terrie E. Taylor,
James G. Kublin,
Fraction K. Dzinjalamala,
Ananías A. Escalante,
Christopher V. Plowe,
Miriam K. Laufer,
Shan TakalaHarrison
Publication year - 2015
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiv078
Subject(s) - dihydropteroate synthase , plasmodium falciparum , sulfadoxine , dhps , sulfadoxine/pyrimethamine , malaria , haplotype , drug resistance , chloroquine , biology , pyrimethamine , virology , genetics , genotype , immunology , gene
In 2007, Malawi replaced sulfadoxine-pyrimethamine (SP) with an artemisinin-based combination therapy as the first-line treatment for uncomplicated Plasmodium falciparum malaria in response to failing SP efficacy. Here we estimate the effect of reduced SP pressure on the prevalence of SP-resistant parasites and the characteristics of the associated selective sweeps flanking the resistance loci.
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