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The emergence and spread of drug resistance to current antimalarial therapies remains a pressing concern, escalating the need for compounds that demonstrate novel modes of action. Diversity-Oriented Synthesis (DOS) libraries bridge the gap between conventional small molecule and natural product libraries, allowing the interrogation of more diverse chemical space in efforts to identify probes of novel parasite pathways.

the journal of infectious diseases (online. university of chicago press)/the journal of infectious diseases

Diversity-Oriented Synthesis Probe Targets<i>Plasmodium falciparum</i>Cytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors

Diversity-Oriented Synthesis Probe TargetsPlasmodium falciparumCytochrome b Ubiquinone Reduction Site and Synergizes With Oxidation Site Inhibitors