Open AccessHuman Papillomavirus 16–Specific T-Cell Responses and Spontaneous Regression of Anal High-Grade Squamous Intraepithelial Lesions
Author(s) -
Winnie Tong,
Kelsee L. Shepherd,
Suzanne M. Garland,
Alan P. Meagher,
David J. Templeton,
Christopher K. Fairley,
Fengyi Jin,
I. Mary Poynten,
John Zaunders,
Richard J. Hillman,
Andrew E. Grulich,
Anthony D. Kelleher,
Andrew Carr
Publication year - 2014
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.69
H-Index - 252
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu461
Subject(s) - squamous intraepithelial lesion , anal cancer , human papillomavirus , koilocyte , papillomaviridae , medicine , squamous cell cancer , lesion , anal canal , cervical cancer , pathology , cancer , oncology , biology , cervical intraepithelial neoplasia , rectum
Most anal cancers are attributable to persistent human papillomavirus type 16 (HPV-16) infection. The anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), frequently regresses spontaneously. We hypothesized that T-cell responses are associated with HSIL regression.
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