Open AccessImpact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults
Author(s) -
S. Todd Callahan,
Mark Wolff,
Heather R. Hill,
Kathryn M. Edwards,
W Keitel,
Robert L. Atmar,
Shital M. Patel,
Hana M. El Sahly,
Flor M. Muñoz,
W. Paul Glezen,
Rebecca C. Brady,
Robert W. Frenck,
David I. Bernstein,
Christopher Harrison,
Mary Anne Jackson,
David K. Swanson,
John W. Newland,
Angela Myers,
Robert A. Livingston,
E. Walter,
Rowena J Dolor,
Kenneth E. Schmader,
Mark J. Mulligan,
Srilatha Edupuganti,
Nadine Rouphael,
J. Whitaker,
Paul Spearman,
Harry Keyserling,
Andi L. Shane,
Allison Ross Eckard,
Lisa A. Jackson,
Steve Frey,
Robert B. Belshe,
Ian D. Graham,
Evan J. Anderson,
Janet A. Englund,
Sara A. Healy,
Patricia Winokur,
Jack T. Stapleton,
Jeffery L. Meier,
Karen Kotloff,
W. Chen,
John Hutter,
I. Stephens,
Steven Wooten,
Anna Wald,
Christine Johnston,
Kathryn M. Edwards,
C. Buddy Creech,
S. Todd Callahan,
on behalf of the NIAID Vaccine and Treatment Evaluation Unit (VTEU) Pandemic HN Vaccine Study Group
Publication year - 2014
Publication title -
the journal of infectious diseases
Language(s) - English
Resource type - Journals
eISSN - 1537-6613
pISSN - 0022-1899
DOI - 10.1093/infdis/jiu245
Subject(s) - medicine , immunogenicity , hemagglutination assay , pandemic , body mass index , immunology , seroconversion , h1n1 pandemic , obesity , influenza a virus , antibody titer , serology , titer , immune system , antibody , virology , virus , covid-19 , disease , infectious disease (medical specialty)
Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
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